Modular microfluidic platform for solubility measurement, nucleation statistics and polymorph screening of active pharmaceutical ingredients: Irbesartan, Rimonabant, Aripiprazole and Sulfathiazole
نویسندگان
چکیده
Drug efficacy strongly relies on the solid state of active pharmaceutical ingredient. Classical solid-state screening methods involve different solvent compositions and supersaturations. Moreover, many repeat experiments needed to address stochasticity nucleation make this approach costly. This paper presents a newly developed modular microfluidic platform that provides universal flexible plug-and-play tool for crystallisation studies without use surfactants. By dissolving powder, our setup generates saturated solutions can be used solubility measurements or distributed in microdroplets. Here, we describe performed forms, stable metastable, molecules (Irbesartan, Rimonabant Aripiprazole) organic aqueous solvents. In addition, provide statistics obtained Sulfathiazole water acetonitrile. Reporting polymorph nucleated find cooling rate influences both polymorphism results, reflecting competition between thermodynamics kinetics. Three unknown forms were discovered, with XRD patterns Raman spectra do not match any referenced form. We also demonstrate limitations microfluidics by cooling: reducing crystalliser volume considerably increases induction time.
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چکیده: فرض کنید که تابعی از اپسیلون یک مجموع نامتناهی از احتمالات موزون مربوط به مجموع های جزئی براساس یک دنباله از متغیرهای تصادفی مستقل و همتوزیع باشد، و همچنین فرض کنید توابعی مانند g و h وجود دارند که هرگاه امید ریاضی توان دوم x متناهی و امیدریاضی x صفر باشد، در این صورت می توان حد حاصلضرب این توابع را بصورت تابعی از امید ریاضی توان دوم x نوشت. حالت عکس نیز برقرار است. همچنین ما با استفاده...
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ژورنال
عنوان ژورنال: Journal of Crystal Growth
سال: 2023
ISSN: ['1873-5002', '0022-0248']
DOI: https://doi.org/10.1016/j.jcrysgro.2023.127252